George was born and raised in Cornwall. The Eustice family have lived and worked in the Camborne and Redruth area for over four hundred years, first working in the mining and engineering industry and then farming at Gwinear, where they have lived for the past 150 years.

After several years working in the family farming business, George gained several years' political campaign experience including the Conservative Party's Head of Press under Michael Howard between 2003 and the 2005 General Election. He was then David Cameron's Press Secretary from June 2005 until the end of 2007 and was part of his campaign team during the leadership contest.

George was first elected as MP for Camborne, Redruth and Hayle in May 2010, and as a member of the Environment and Rural Affairs Select Committee that same year before being appointed Parliamentary Under-Secretary of State at the Department for Environment, Food and Rural Affairs (DEFRA) in 2013, and then Minister of State at DEFRA in 2015. In 2020 he became Secretary of State at DEFRA. During his final two years at the department he introduced the Agriculture Act 2020, the Fisheries Act 2020 and the Environment Act 2021